PICALM anticorps (N-Term)

N° du produit ABIN500493

Cet anticorps anti-PICALM est un anticorps Lapin Polyclonal détectant PICALM dans WB et EIA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour PICALM anticorps (N-Term) (ABIN500493)

Antigène: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PICALM est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-PICALM anticorps

Épitope: N-Term

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: PICALM antibody was raised against a 15 amino acid peptide from near the amino terminus of human PICALM.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur PICALM

Antigène: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Autre désignation: PICALM

Sujet: PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).Synonyms: CALM, Clathrin assembly lymphoid myeloid leukemia protein, Phosphatidylinositol-binding clathrin assembly protein

ID gène: 8301

NCBI Accession: NP_009097

UniProt: Q13492

Pathways: Synaptic Membrane